Sensing of nutrients and microbes in the gut.
Identifieur interne : 000A14 ( Main/Exploration ); précédent : 000A13; suivant : 000A15Sensing of nutrients and microbes in the gut.
Auteurs : Shrinivas Bishu [États-Unis]Source :
- Current opinion in gastroenterology [ 1531-7056 ] ; 2016.
Descripteurs français
- KwdFr :
- Homéostasie (MeSH), Humains (MeSH), Microbiome gastro-intestinal (immunologie), Métabolisme énergétique (physiologie), Phénomènes physiologiques nutritionnels (immunologie), Sérine-thréonine kinases TOR (métabolisme), Transduction du signal (physiologie), Tube digestif (immunologie), Tube digestif (microbiologie), Tube digestif (physiologie).
- MESH :
- immunologie : Microbiome gastro-intestinal, Phénomènes physiologiques nutritionnels, Tube digestif.
- microbiologie : Tube digestif.
- métabolisme : Sérine-thréonine kinases TOR.
- physiologie : Métabolisme énergétique, Transduction du signal, Tube digestif.
- Homéostasie, Humains.
English descriptors
- KwdEn :
- Energy Metabolism (physiology), Gastrointestinal Microbiome (immunology), Gastrointestinal Tract (immunology), Gastrointestinal Tract (microbiology), Gastrointestinal Tract (physiology), Homeostasis (MeSH), Humans (MeSH), Nutritional Physiological Phenomena (immunology), Signal Transduction (physiology), TOR Serine-Threonine Kinases (metabolism).
- MESH :
- chemical , metabolism : TOR Serine-Threonine Kinases.
- immunology : Gastrointestinal Microbiome, Gastrointestinal Tract, Nutritional Physiological Phenomena.
- microbiology : Gastrointestinal Tract.
- physiology : Energy Metabolism, Gastrointestinal Tract, Signal Transduction.
- Homeostasis, Humans.
Abstract
PURPOSE OF REVIEW
Sensing of nutrients and microbes in the gut are fundamental processes necessary for life. This review aims to provide an overview of the basic background and new data on cellular nutrient, energy, and microbe sensors.
RECENT FINDINGS
The nutrient sensors 5' adenosine monophosphate-activated protein kinase, activating transcription factor 4 and mechanistic target of rapamycin (mTOR) are critical in control of the cell cycle. Recent data demonstrate their role in metabolic syndrome, in cell growth, and as therapeutic targets. Regulation of mTOR by the amino acids is the subject of intense investigation. Recent studies have further elucidated the exact mechanism of amino acid-dependent mTOR regulation. Pathogen recognition receptors (PRRs) are receptors that recognize conserved microbial molecules. New data demonstrate how lymphocyte-specific PRRs are necessary to maintain homeostasis. Moreover, new studies explore the role of PRRs in controlling the gut bacterial and fungal microbiome.
SUMMARY
Nutrient sensing molecules are central to cell growth and metabolism and are implicated in cancer and the metabolic syndrome. Regulation of nutrient sensors is complex, and may be amenable to therapeutic targeting. Microbial sensors play critical roles in homeostasis and maintenance of the gut fungal and bacterial microbiome.
DOI: 10.1097/MOG.0000000000000246
PubMed: 26836123
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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This review aims to provide an overview of the basic background and new data on cellular nutrient, energy, and microbe sensors.</p></div><div type="abstract" xml:lang="en"><p><b>RECENT FINDINGS</b></p><p>The nutrient sensors 5' adenosine monophosphate-activated protein kinase, activating transcription factor 4 and mechanistic target of rapamycin (mTOR) are critical in control of the cell cycle. Recent data demonstrate their role in metabolic syndrome, in cell growth, and as therapeutic targets. Regulation of mTOR by the amino acids is the subject of intense investigation. Recent studies have further elucidated the exact mechanism of amino acid-dependent mTOR regulation. Pathogen recognition receptors (PRRs) are receptors that recognize conserved microbial molecules. New data demonstrate how lymphocyte-specific PRRs are necessary to maintain homeostasis. Moreover, new studies explore the role of PRRs in controlling the gut bacterial and fungal microbiome.</p></div><div type="abstract" xml:lang="en"><p><b>SUMMARY</b></p><p>Nutrient sensing molecules are central to cell growth and metabolism and are implicated in cancer and the metabolic syndrome. Regulation of nutrient sensors is complex, and may be amenable to therapeutic targeting. Microbial sensors play critical roles in homeostasis and maintenance of the gut fungal and bacterial microbiome.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26836123</PMID><DateCompleted><Year>2016</Year><Month>12</Month><Day>13</Day></DateCompleted><DateRevised><Year>2016</Year><Month>12</Month><Day>30</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1531-7056</ISSN><JournalIssue CitedMedium="Internet"><Volume>32</Volume><Issue>2</Issue><PubDate><Year>2016</Year><Month>Mar</Month></PubDate></JournalIssue><Title>Current opinion in gastroenterology</Title><ISOAbbreviation>Curr Opin Gastroenterol</ISOAbbreviation></Journal><ArticleTitle>Sensing of nutrients and microbes in the gut.</ArticleTitle><Pagination><MedlinePgn>86-95</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1097/MOG.0000000000000246</ELocationID><Abstract><AbstractText Label="PURPOSE OF REVIEW" NlmCategory="OBJECTIVE">Sensing of nutrients and microbes in the gut are fundamental processes necessary for life. This review aims to provide an overview of the basic background and new data on cellular nutrient, energy, and microbe sensors.</AbstractText><AbstractText Label="RECENT FINDINGS" NlmCategory="RESULTS">The nutrient sensors 5' adenosine monophosphate-activated protein kinase, activating transcription factor 4 and mechanistic target of rapamycin (mTOR) are critical in control of the cell cycle. Recent data demonstrate their role in metabolic syndrome, in cell growth, and as therapeutic targets. Regulation of mTOR by the amino acids is the subject of intense investigation. Recent studies have further elucidated the exact mechanism of amino acid-dependent mTOR regulation. Pathogen recognition receptors (PRRs) are receptors that recognize conserved microbial molecules. New data demonstrate how lymphocyte-specific PRRs are necessary to maintain homeostasis. Moreover, new studies explore the role of PRRs in controlling the gut bacterial and fungal microbiome.</AbstractText><AbstractText Label="SUMMARY" NlmCategory="CONCLUSIONS">Nutrient sensing molecules are central to cell growth and metabolism and are implicated in cancer and the metabolic syndrome. Regulation of nutrient sensors is complex, and may be amenable to therapeutic targeting. Microbial sensors play critical roles in homeostasis and maintenance of the gut fungal and bacterial microbiome.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Bishu</LastName><ForeName>Shrinivas</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Medicine, Division of Gastroenterology and Hepatology, University of Michigan, Michigan, USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Curr Opin Gastroenterol</MedlineTA><NlmUniqueID>8506887</NlmUniqueID><ISSNLinking>0267-1379</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>EC 2.7.1.1</RegistryNumber><NameOfSubstance UI="C546842">MTOR protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.1.1</RegistryNumber><NameOfSubstance UI="D058570">TOR Serine-Threonine Kinases</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D004734" MajorTopicYN="N">Energy Metabolism</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000069196" MajorTopicYN="N">Gastrointestinal Microbiome</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D041981" MajorTopicYN="N">Gastrointestinal Tract</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006706" MajorTopicYN="N">Homeostasis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009747" MajorTopicYN="N">Nutritional Physiological Phenomena</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D058570" MajorTopicYN="N">TOR Serine-Threonine Kinases</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>2</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>2</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>12</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26836123</ArticleId><ArticleId IdType="doi">10.1097/MOG.0000000000000246</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Michigan</li></region></list><tree><country name="États-Unis"><region name="Michigan"><name sortKey="Bishu, Shrinivas" sort="Bishu, Shrinivas" uniqKey="Bishu S" first="Shrinivas" last="Bishu">Shrinivas Bishu</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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